Comparability of Wound Healing Activity Between Hepar Sulph and Aloe Vera: A Systematic Review
Abstract
Aloe vera, a historic remedy, enhances wound dressings’ therapeutic effects, promoting wound constriction and tissue regeneration. On the other hand, hepar sulph has innovative wound care approaches include dressing for managing chronic leg ulcers, particularly diabetic foot ulcers, with minimal side effects. This review study aims to compare the effectiveness of hepar sulph and aloe vera in wound healing activity. Articles were searched from different search engines by using the keywords. ‘hepar sulph’, ‘aloe vera’, ‘wound healing activity’, ‘prevention’. Our main inclusion criteria were we choose only human study. Thirteen articles are selected from a total of 58 articles. From this review it is concluded that both aloe vera and hepar sulph accomplish their goals in distinct ways.
Keywords:
wound healing, hepar sulph, aloe vera
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References
Avijgan, M., Kamran, A., & Abedini, A. (2016). Effectiveness of Aloe vera gel in chronic ulcers in comparison with conventional treatments. Iranian journal of medical sciences, 41(3 Suppl), S30.
Banu, A., Sathyanarayana, B. C., & Chattannavar, G. (2012). Efficacy of fresh Aloe vera gel against multi-drug resistant bacteria in infected leg ulcers. The Australasian medical journal, 5(6), 305. https://doi.org/10.4066/AMJ.2012.1301
Bidwalkar, D. S., & Baswal, D. H. (2021). Acne conglobate: An evidence-based case report treated with Individualized Homoeopathic medicine. International Journal of Homoeopathic Sciences, 5(4), 291–293. https://doi.org/10.33545/26164485.2021.v5.i4e.485
Boudreau, M. D., & Beland, F. A. (2006). An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. Journal of Environmental Science and Health Part C, 24(1), 103-154. https://doi.org/10.1080/10590500600614303
Bunyapraphatsara, N., Jirakulchaiwong, S., Thirawarapan, S., & Manonukul, J. (1996). The efficacy of Aloe vera cream in the treatment of first, second and third degree burns in mice. Phytomedicine, 2(3), 247-251. https://doi.org/10.1016/S0944-7113(96)80050-X.
Dalpati, N., Rai, S. K., Singh, D., Dash, S. P., Sarangi, S. S., Nayak, M., & Sarangi, P. P. (2023). Homoeopathic medicines modulate inflammatory functions and adhesion receptor expression in human blood cells: An in vitro study. Indian Journal of Research in Homoeopathy, 17(3), 153-166. https://doi.org/10.53945/2320-7094.1321
Daphne, T. L., & Prince, V. (2019). A study to assess the effectiveness of Aloe Vera gel dressing on wound status among patients with diabetes mellitus in government hospital, Dindigul. International Journal of Advances in Nursing Management, 7(2), 159-162. https://doi.org/10.5958/2454-2652.2019.00038.6
Dat, A. D., Poon, F., Pham, K. B., & Doust, J. (2012). Aloe vera for treating acute and chronic wounds. Cochrane database of systematic reviews, (2). https://doi.org/10.1002/14651858.CD008762.pub2
Demarque D, Jouanny J, Poitevin B, Saint-Jean Y. Pharmacology and Homeopathic Materia Medica. 3rd ed. Sainte-Foy-lès-Lyon: CEDH; 2007.
Gadde, P., Narasimhulu, D., & Rompicherla, K. (2018). Integrative management of diabetic foot ulcer with Homoeopathy and standard care. Indian Journal of Research in Homoeopathy, 12(3), 180-186. https://doi.org/10.4103/ijrh.ijrh_42_17
Gadde, P., Narasimhulu, D., & Rompicherla, K. (2018). Integrative management of diabetic foot ulcer with Homoeopathy and standard care. Indian Journal of Research in Homoeopathy, 12(3), 180-186. https://doi.org/10.4103/ijrh.ijrh_42_17
Ghaffarzadegan, R., Alizadeh, S. A., Ghaffarzadegan, R., Haji Agaei, R., & Ahmadlou, M. (2013). Effect of aloe vera gel, compared to 1% silver sulfadiazine cream on second-degree burn wound healing. Complementary Medicine Journal, 3(1), 418-428.
Greeshma, I. K., & Dastagiri, P. (2021). A review of the effectiveness of homoeopathy in the management of chronic leg ulcers. Int J Homoeopath Sci, 5(01), 16-20. https://doi.org/10.33545/26164485.2021.v5.i1a.285
Heck, E., Head, M., Nowak, D., Helm, P., & Baxter, C. (1981). Aloe vera (gel) cream as a topical treatment for outpatient burns. Burns, 7(4), 291-294. https://doi.org/10.1016/0305-4179(81)90112-1
Jangda, S., & Harihar, P. (2022). Scope of Homoeopathic Management of Chronic Suppurative Otitis Media-A Case Report. Journal of Medical and Pharmaceutical Innovation, 9(48). . Available from: https://www.jmedpharm.com/index.php/home/article/view/223/254 accessed on 15th February 2024.
Kiran, P. S. S., Chiluka, R. L., Vineela, K., & Shivani, B. (2023). A case of venous leg ulcer treated with hepar sulphuricum. International Journal of Homoeopathic Sciences, 7(4), 625-627.
Kumar, P. (2024). Treatment of Eczema by Homoeopathic Medicine-A Case Report. International Journal of AYUSH Case Reports, 8(1), 127-132. https://www.ijacare.in/index.php/ijacare/article/view/537
Liang, J., Cui, L., Li, J., Guan, S., Zhang, K., & Li, J. (2021). Aloe vera: a medicinal plant used in skin wound healing. Tissue Engineering Part B: Reviews, 27(5), 455-474. https://doi.org/10.1089/ten.teb.2020.0236
Maniei, M., Aghababaeian, H., Karimi, H., Firozzadeh, K., & Amirgholami, N. (2019). The use of aloe vera after infrared therapy in the treatment of a diabetic foot ulcer: a case report. Journal of Biochemical Technology, 10(2-2019), 43-49. . Available from: https://jbiochemtech.com/article/the-use-of-aloe-vera-after-infrared-therapy-in-the treatment-of-a-diabetic-foot-ulcer-a-case-report accessed on 15th April 2024
Muhammed, H. (2023). Management of erythrodermic psoriasis with individualised homoeopathy: An evidence-based case report. Indian Journal of Research in Homoeopathy, 17(2), 94-102. https://doi.org/10.53945/2320-7094.1235
Ozgok Kangal, M. K., & Regan, J. P. (2023). Wound Healing. Stat Pearls. Stat Pearls Publishing. StatPearls Publishing; 2024 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535406/
Pasalkar, A. D., Kathade, S. A., Jadhav, A. B., Kunchiraman, B. N., & Shinde, C. H. (2019). Study the Anti-Bacterial Activity of Homoeopathic Medicines against Staphylococcus epidermidis in-vitro. Int. J Health Sci Res, 9(12), 49-53. Available from: https://www.ijhsr.org/IJHSR_Vol.9_Issue.12_Dec2019/7.pdf. accessed on 27th April 2024.
Panahi, Y., Izadi, M., Sayyadi, N., Rezaee, R., Jonaidi-Jafari, N., Beiraghdar, F., ... & Sahebkar, A. (2015). Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds. Journal of wound care, 24(10), 459-465. https://doi.org/10.12968/jowc.2015.24.10.459
Potdar, S. (2022). Effectiveness of homoeopathy for the treatment and management of idiopathic granulomatous mastitis in women: A case series. Indian Journal of Research in Homoeopathy, 16(1), 5. https://doi.org/10.53945/2320-7094.1063
Reddy, C. U., Reddy, K. S., & Reddy, J. J. (2011). Aloe vera-A wound healer. Asian Journal of Oral Health & Allied Sciences-Volume, 1(1), 91–92.
Sahu, P. K., Giri, D. D., Singh, R., Pandey, P., Gupta, S., Shrivastava, A. K., & Pandey, K. D. (2013). Therapeutic and medicinal uses of Aloe vera: a review. Pharmacology & Pharmacy, 4(08), 599–610. http://dx.doi.org/10.4236/pp.2013.48086
Sathye, S. (2016). Evidence-based Homoeopathy: A case of corneal abscess. Indian Journal of Research in Homoeopathy, 10(3), 206-210. https://doi.org/10.4103/0974-7168.188242
Shelton, R. M. (1991). Aloe vera: its chemical and therapeutic properties. International journal of dermatology, 30(10). 679–83. https://doi.org/10.1111/j.1365-4362.1991.tb02607.x
Somboonwong, J., Thanamittramanee, S., Jariyapongskul, A., & Patumraj, S. (2000). Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 83(4), 417–425.
Subramanian, S., Kumar, D. S., & Arulselvan, P. (2006). Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J Biochem. 1, 178–85. http://www.academicjournals.net
Taylor, N., & Gough, A. (2017). No way to treat a friend: Lifting the lid on complementary and alternative veterinary medicine. 5m Books Ltd.
Valdés, D. E. D., Navarro, B. D., García, L. R. G., Francesena, D. V., & Díaz, B. M. D. (2018). Use of Hepar sulphur for treatment of alveolitis. Revista de Homeopatia, 81(1/2), 23-28. Available at : https://pesquisa.bvsalud.org/portal/resource/pt/biblio-908621
van Koppen, C. J., & Hartmann, R. W. (2015). Advances in the treatment of chronic wounds: a patent review. Expert opinion on therapeutic patents, 25(8), 931-937. https://doi.org/10.1517/13543776.2015.1045879
Viswanathan, V., Kesavan, R., Kavitha, K. V., & Kumpatla, S. (2011). A pilot study on the effects of a polyherbal formulation cream on diabetic foot ulcers. Indian Journal of Medical Research, 134(2), 168-173.
Banu, A., Sathyanarayana, B. C., & Chattannavar, G. (2012). Efficacy of fresh Aloe vera gel against multi-drug resistant bacteria in infected leg ulcers. The Australasian medical journal, 5(6), 305. https://doi.org/10.4066/AMJ.2012.1301
Bidwalkar, D. S., & Baswal, D. H. (2021). Acne conglobate: An evidence-based case report treated with Individualized Homoeopathic medicine. International Journal of Homoeopathic Sciences, 5(4), 291–293. https://doi.org/10.33545/26164485.2021.v5.i4e.485
Boudreau, M. D., & Beland, F. A. (2006). An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. Journal of Environmental Science and Health Part C, 24(1), 103-154. https://doi.org/10.1080/10590500600614303
Bunyapraphatsara, N., Jirakulchaiwong, S., Thirawarapan, S., & Manonukul, J. (1996). The efficacy of Aloe vera cream in the treatment of first, second and third degree burns in mice. Phytomedicine, 2(3), 247-251. https://doi.org/10.1016/S0944-7113(96)80050-X.
Dalpati, N., Rai, S. K., Singh, D., Dash, S. P., Sarangi, S. S., Nayak, M., & Sarangi, P. P. (2023). Homoeopathic medicines modulate inflammatory functions and adhesion receptor expression in human blood cells: An in vitro study. Indian Journal of Research in Homoeopathy, 17(3), 153-166. https://doi.org/10.53945/2320-7094.1321
Daphne, T. L., & Prince, V. (2019). A study to assess the effectiveness of Aloe Vera gel dressing on wound status among patients with diabetes mellitus in government hospital, Dindigul. International Journal of Advances in Nursing Management, 7(2), 159-162. https://doi.org/10.5958/2454-2652.2019.00038.6
Dat, A. D., Poon, F., Pham, K. B., & Doust, J. (2012). Aloe vera for treating acute and chronic wounds. Cochrane database of systematic reviews, (2). https://doi.org/10.1002/14651858.CD008762.pub2
Demarque D, Jouanny J, Poitevin B, Saint-Jean Y. Pharmacology and Homeopathic Materia Medica. 3rd ed. Sainte-Foy-lès-Lyon: CEDH; 2007.
Gadde, P., Narasimhulu, D., & Rompicherla, K. (2018). Integrative management of diabetic foot ulcer with Homoeopathy and standard care. Indian Journal of Research in Homoeopathy, 12(3), 180-186. https://doi.org/10.4103/ijrh.ijrh_42_17
Gadde, P., Narasimhulu, D., & Rompicherla, K. (2018). Integrative management of diabetic foot ulcer with Homoeopathy and standard care. Indian Journal of Research in Homoeopathy, 12(3), 180-186. https://doi.org/10.4103/ijrh.ijrh_42_17
Ghaffarzadegan, R., Alizadeh, S. A., Ghaffarzadegan, R., Haji Agaei, R., & Ahmadlou, M. (2013). Effect of aloe vera gel, compared to 1% silver sulfadiazine cream on second-degree burn wound healing. Complementary Medicine Journal, 3(1), 418-428.
Greeshma, I. K., & Dastagiri, P. (2021). A review of the effectiveness of homoeopathy in the management of chronic leg ulcers. Int J Homoeopath Sci, 5(01), 16-20. https://doi.org/10.33545/26164485.2021.v5.i1a.285
Heck, E., Head, M., Nowak, D., Helm, P., & Baxter, C. (1981). Aloe vera (gel) cream as a topical treatment for outpatient burns. Burns, 7(4), 291-294. https://doi.org/10.1016/0305-4179(81)90112-1
Jangda, S., & Harihar, P. (2022). Scope of Homoeopathic Management of Chronic Suppurative Otitis Media-A Case Report. Journal of Medical and Pharmaceutical Innovation, 9(48). . Available from: https://www.jmedpharm.com/index.php/home/article/view/223/254 accessed on 15th February 2024.
Kiran, P. S. S., Chiluka, R. L., Vineela, K., & Shivani, B. (2023). A case of venous leg ulcer treated with hepar sulphuricum. International Journal of Homoeopathic Sciences, 7(4), 625-627.
Kumar, P. (2024). Treatment of Eczema by Homoeopathic Medicine-A Case Report. International Journal of AYUSH Case Reports, 8(1), 127-132. https://www.ijacare.in/index.php/ijacare/article/view/537
Liang, J., Cui, L., Li, J., Guan, S., Zhang, K., & Li, J. (2021). Aloe vera: a medicinal plant used in skin wound healing. Tissue Engineering Part B: Reviews, 27(5), 455-474. https://doi.org/10.1089/ten.teb.2020.0236
Maniei, M., Aghababaeian, H., Karimi, H., Firozzadeh, K., & Amirgholami, N. (2019). The use of aloe vera after infrared therapy in the treatment of a diabetic foot ulcer: a case report. Journal of Biochemical Technology, 10(2-2019), 43-49. . Available from: https://jbiochemtech.com/article/the-use-of-aloe-vera-after-infrared-therapy-in-the treatment-of-a-diabetic-foot-ulcer-a-case-report accessed on 15th April 2024
Muhammed, H. (2023). Management of erythrodermic psoriasis with individualised homoeopathy: An evidence-based case report. Indian Journal of Research in Homoeopathy, 17(2), 94-102. https://doi.org/10.53945/2320-7094.1235
Ozgok Kangal, M. K., & Regan, J. P. (2023). Wound Healing. Stat Pearls. Stat Pearls Publishing. StatPearls Publishing; 2024 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK535406/
Pasalkar, A. D., Kathade, S. A., Jadhav, A. B., Kunchiraman, B. N., & Shinde, C. H. (2019). Study the Anti-Bacterial Activity of Homoeopathic Medicines against Staphylococcus epidermidis in-vitro. Int. J Health Sci Res, 9(12), 49-53. Available from: https://www.ijhsr.org/IJHSR_Vol.9_Issue.12_Dec2019/7.pdf. accessed on 27th April 2024.
Panahi, Y., Izadi, M., Sayyadi, N., Rezaee, R., Jonaidi-Jafari, N., Beiraghdar, F., ... & Sahebkar, A. (2015). Comparative trial of Aloe vera/olive oil combination cream versus phenytoin cream in the treatment of chronic wounds. Journal of wound care, 24(10), 459-465. https://doi.org/10.12968/jowc.2015.24.10.459
Potdar, S. (2022). Effectiveness of homoeopathy for the treatment and management of idiopathic granulomatous mastitis in women: A case series. Indian Journal of Research in Homoeopathy, 16(1), 5. https://doi.org/10.53945/2320-7094.1063
Reddy, C. U., Reddy, K. S., & Reddy, J. J. (2011). Aloe vera-A wound healer. Asian Journal of Oral Health & Allied Sciences-Volume, 1(1), 91–92.
Sahu, P. K., Giri, D. D., Singh, R., Pandey, P., Gupta, S., Shrivastava, A. K., & Pandey, K. D. (2013). Therapeutic and medicinal uses of Aloe vera: a review. Pharmacology & Pharmacy, 4(08), 599–610. http://dx.doi.org/10.4236/pp.2013.48086
Sathye, S. (2016). Evidence-based Homoeopathy: A case of corneal abscess. Indian Journal of Research in Homoeopathy, 10(3), 206-210. https://doi.org/10.4103/0974-7168.188242
Shelton, R. M. (1991). Aloe vera: its chemical and therapeutic properties. International journal of dermatology, 30(10). 679–83. https://doi.org/10.1111/j.1365-4362.1991.tb02607.x
Somboonwong, J., Thanamittramanee, S., Jariyapongskul, A., & Patumraj, S. (2000). Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 83(4), 417–425.
Subramanian, S., Kumar, D. S., & Arulselvan, P. (2006). Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J Biochem. 1, 178–85. http://www.academicjournals.net
Taylor, N., & Gough, A. (2017). No way to treat a friend: Lifting the lid on complementary and alternative veterinary medicine. 5m Books Ltd.
Valdés, D. E. D., Navarro, B. D., García, L. R. G., Francesena, D. V., & Díaz, B. M. D. (2018). Use of Hepar sulphur for treatment of alveolitis. Revista de Homeopatia, 81(1/2), 23-28. Available at : https://pesquisa.bvsalud.org/portal/resource/pt/biblio-908621
van Koppen, C. J., & Hartmann, R. W. (2015). Advances in the treatment of chronic wounds: a patent review. Expert opinion on therapeutic patents, 25(8), 931-937. https://doi.org/10.1517/13543776.2015.1045879
Viswanathan, V., Kesavan, R., Kavitha, K. V., & Kumpatla, S. (2011). A pilot study on the effects of a polyherbal formulation cream on diabetic foot ulcers. Indian Journal of Medical Research, 134(2), 168-173.
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How to Cite
Muslim, D., Said, F., & Nambiar, N. (2024). Comparability of Wound Healing Activity Between Hepar Sulph and Aloe Vera: A Systematic Review. International Journal of Advancement in Life Sciences Research, 7(4), 12-20. https://doi.org/https://doi.org/10.31632/ijalsr.2024.v07i04.002
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Review Articles
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