Is There Any Effect Of Addictions In Arsenic Induced Oral Carcinoma?
Effect of various addictions in arsenic related OSCC
Abstract
Background- The association of various addictions with oral squamous cell carcinoma (OSCC) has been well established. But it’s any possible link with metal toxicity has not been studied in the context of this carcinoma.
Aim- To correlate the variation in the effect of various addictions with arsenic toxicity in the development of OSCC in the study population.
Settings and design- It is a case-control study. Ethical clearance was obtained from the institutional committee. A total of 104 oral malignant, 103 premalignant and 200 age and sex matched healthy individuals were selected for the study. The history of addictions of case and controls was collected from questionnaire.
Methods and material- On proper consent of cases & controls, the hair samples were collected for arsenic estimation by flow injection hydride generation atomic absorption spectrometry and the peripheral venous blood samples were processed for human leukocyte culture followed by Giemsa staining for the detection of chromosomal abnormality.
Statistical analysis used- Student t test, logistic regression by R software and correlation analysis by Graph Pad software.
Results- Significant correlation was observed between arsenic toxicity & OSCC (p value = 2.18e-06 ***). Smoking tobacco (r value 0.5365) was more significant over chewing tobacco (r value 0.4804). 3% of malignant cases showed chromosomal break.
Conclusion- Statistically significant correlation among arsenic, addictions & OSCC in this study may indicate an associative role between the two factors. However, the study could not define any correlation with cytogenetic damage.
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References
Arnold, H. L., Odam, R. B., James, W. D. (1990). Disease of the skin. Clinical dermatology. In: Saunders, W.B. (Ed.), Philadelphia, pp. 121–122.
Aslesh, O. P., Paul, S., Paul, L., Jayasree, A. K. (2015). High Prevalence of Tobacco Use and Associated Oral Mucosal Lesion Among Interstate Male Migrant Workers in Urban Kerala, India. Iranian Journal of Cancer Prevention, 8(6), e3876. http://doi.org/10.17795/ijcp-3876
Atkinson, L., Chester, I. C., Smyth, F.G., Ten, S. (1964). Oral cancer in New Guinea. A study in demography and etiology. Cancer, 17, pp.1289–98. [PubMed: 14236762]
Banerjee, N., Giri, A. (2014). Arsenic Induced Health Effects, Genetic Damage and Genetic Variants in the Population Exposed to Arsenic through Drinking Water in West Bengal. Proc Indian Natn Sci Acad, 80 No. 3 pp. 565-581. doi: 10.16943/ptinsa/2014/v80i3/55130.
Bouda, M., Gorgoulis, V. G., Kastrinakis, N. G., Giannoudis, A., Tsoli, E., Danassi, Afentaki, D., et al. (2000). High risk HPV types are frequently detected in potentially malignant and malignant oral lesions, but not in normal oral mucosa. Modern Pathology, 13:644–53. [PubMed: 10874669]
Bronstein, A. C., Spyker, D. A., Cantilena, L. R. Jr., Green, J. L., Rumack, B. H., Dart, R. C. (2011). 2010 Annual Report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 28th Annual Report. Clin Toxicol (Phila), 49(10), pp.91041. [Medline].
Chakraborti, D., Das, B., Rahman, M. M., Chowdhury, U. K., Biswas, B., Goswami, A. B., et al. (2009). Status of groundwater arsenic contamination in the state of West Bengal, India: a 20-year study report. Mol. Nutr. Food Res, 53, pp.542 – 51.doi: 10.1002/mnfr.200700517.
Coelho, K. R. (2012). Challenges of the Oral Cancer Burden in India. Journal of Cancer Epidemiology, http://dx.doi.org/10.1155/2012/701932
El-Zaemey, S., Schüz, J., Leon, M. E. (2015). Qat Chewing and Risk of Potentially Malignant and Malignant Oral Disorders: A Systematic Review. Int J Occup Environ Med, 6(3), pp.129-43. doi: 10.15171/ijoem.2015.537.
Epstein, J. B., Zhang, L., Rosin, M. (2002). Advances in the diagnosis of oral premalignant and malignant lesions. J Can Dent Assoc, 68, pp.617-21.
Fazeli, Z., Pourhoseingholi, M. A., Pourhoseingholi, A., Vahedi, M., Zali, M. R. (2011). Mortality of oral cavity cancer in Iran. Asian Pacific Journal of Cancer Prevention, 12, pp.2763–6.
Gupta, S., Singh, R., Gupta, O. P., Tripathi, A. (2014). Prevalence of oral cancer and pre-cancerous lesions and the association with numerous risk factors in North India: A hospital based study. National Journal of Maxillofacial Surgery, 5(2), pp.142–148. http://doi.org/10.4103/0975-5950.154816.
Ho, P. S., Yang, Y. H., Shieh, T.Y., Huang, I. Y., Chen, Y. K., Lin, K. N., et al. (2007) Consumption of areca quid, cigarettes, and alcohol related to the comorbidity of oral submucous fibrosis and oral cancer. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 104, pp.647-52.
Juntanong, N., Siewchaisakul, P., Bradshaw, P., Vatanasapt, P., Chen, S. L., Yen, A. M., Chen, T. H., Promthet, S. (2016). Prevalence and Factors Associated with Oral Pre-Malignant Lesions in Northeast Thailand. Asian Pac J Cancer Prev, 17(8), pp.4175-9.
Kadashetti, V., Chaudhary, M., Patil, S., Gawande, M., Shivakumar, KM., Patil, S., Pramod, R. C. (2015). Analysis
National Research Council. (1999). Arsenic in Drinking Water. Washington, DC: The National Academies Press, https://doi.org/10.17226/6444.
of various risk factors affecting potentially malignant disorders and oral cancer patients of Central India. J Cancer Res Ther, 11(2), pp.280-6. doi: 10.4103/0973-1482.151417.
Pal, P., Halder, A. (2018). Is There Any Role of Arsenic Toxicity in HPV Related Oral Squamous Cell Carcinoma? Biological Trace Element Research, doi: 10.1007/s12011-018-1419-6.
Pal, P., Raychowdhury, R., Dolai, T. K., Roy, S., Dastidar, R., Halder, A. (2017). Study of arsenic exposure in oral/oropharyngeal carcinoma in West Bengal. Int J Occup Med Environ Health, 30 (2), pp.271-279. doi: 10.13075/ijomeh.1896.00806.
Pratik, P., Desai, V. D. (2015). Prevalence of habits and oral mucosal lesions in Jaipur, Rajasthan. Indian J Dent Res, 26(2), pp.196-9. doi: 10.4103/0970-9290.159166.
Ranganathan, K., Rooban, T., Rao, U. M. (2015). Oral squamous cell carcinoma in patients with and without predisposing habits in glossal and extra-glossal site: An institutional experience in South India. Indian J Cancer, 52(4), pp.625-7. doi: 10.4103/0019-509X.178444.
Ratnaike, R. N. (2003) Acute and chronic arsenic toxicity. Postgraduate Med J, 79:391–6.[PMCID: PMC1742758]
Rodriguez, T., Altieri, A., Chatenoud, L., Gallus, S., Bosetti, C., Negri, E., Franceschi, S., Levi, F., Talamini, R., La, Vecchia, C. (2004). Risk factors for oral and pharyngeal cancer in young adults. Oral Oncology, 40 (2), pp. 207–13. PMID 14693246. doi:10.1016/j.oraloncology.2003.08.014
Sharma, J. D., Kalita, M., Barman, D., Sharma, A., Lahon, R., Barbhuiya, J. A., Deka, B., Kataki, A. C. (2016). Cancer statistics in Kamrup urban district: Incidence and mortality in 2007-2011. Indian J Cancer, 53(4), pp.600-606. doi: 10.4103/0019-509X.204764.
Su, C. C., Lin, Y. Y., Chang, T. K., Chiang, C. T., Chung, J. A., Hsu, Y. Y., Lian, I. B. (2010). Incidence of oral cancer in relation to nickel and arsenic concentrations in farm soils of patients’ residential areas in Taiwan. Bio Med Central Public Health, 10:67.doi: 10.1186/1471-2458-10-67.
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