Formulation of Antioxidant Gel Preparations on the Cherry (Muntingia calabura L.) Extract from Kupang, East Nusa Tenggara Based on AQUPEC 505 HV

Ni Nyoman Yuliani; Jefrin Sambara; Yulius Baki Korassa

doi:10.31632/ijalsr.2021.v04i02.004

Ni Nyoman Yuliani Department of Pharmacy, Kupang Health Polytechnic of Health Ministry, Indonesia https://orcid.org/0000-0001-8998-9940
Jefrin Sambara Department of Pharmacy, Kupang Health Polytechnic of Health Ministry, Indonesia
Yulius Baki Korassa Department of Pharmacy, Kupang Health Polytechnic of Health Ministry, Indonesia

DOI https://doi.org/10.31632/ijalsr.2021.v04i02.004

Abstract

Cherry (Muntingia calabura L.) from Kupang, East Nusa Tenggara is a local fruit in Indonesia which has many benefits for health. One of compounds contained in Cherry is polyphenol functioning as antioxidant. The purpose of this study was to obtain information about antioxidant activity contained in Cherry in the form of extract or gel preparations with different base of aqupec 505 HV with routine comparison. Methods: The method used in this study was quantitative analysis. The cherry was extracted by using reflux method with 70% ethanol solvent and the quantitative testing of antioxidant activity through DPPH method with methanol solvent. For the qualitative one, Thin Layer Chromatography was used with mobile phase of butanol: acetic acid: water (4:1:5). Results: From the physical quality testing of gel preparations, it was obtained stable result in the room-temperature storage and the result of physical quality testing of formula 3 was totally effective to be used on the skin. From the antioxidant activity testing of Cherry extract, it showed that the value of IC₅₀ is 68.50 ppm. On the formula 1 (aqupec 505 HV 0.5%), the value of IC₅₀ is 189.32 ppm. On the formula 2 (aqupec 505 HV 1%), the value of IC₅₀ is 186.95 ppm. On the formula 3 (aqupec 505 HV 1.5%), the value of IC₅₀ is 184.75 ppm. On the formula 4 (aqupec 505 HV 2%), the value of IC₅₀ is 186.60 ppm. On the formula 5 (aqupec 505 HV 1.5% regularly), the value of IC₅₀ is 174.73 ppm. The results of this study showed that the gel which was made was safe to use and the most effective one was on the formula 5 which obtained IC₅₀as many as 186.60 ppm.

Keywords: Antioxidant; Cherry extract; Gel; Aqupec 505 HV

Downloads

Download data is not yet available.

References

Beconcini, D., Felice, F., Fabiano, A., Sarmento, B., Zambito, Y., & Di Stefano, R. (2020). Antioxidant and anti-inflammatory properties of cherry extract: nanosystems-based strategies to improve endothelial function and intestinal absorption. Foods, 9(2), 207.
Cooper, J. W. (1967). Cooper and gunn's dispensing for pharmaceutical students. Pitman Medical Publishing Company.
Draelos, Z. D. (2005). Cosmetic formulation of skin care products (pp. 25-26). CRC Press.
Marliani, L. (2014). Aktivitas antioksidan daun dan buah jamblang (syzigium cumini l.) Skeel. Prosiding SNaPP: Sains, Teknologi, 4(1), 201-206.
Molyneux, P. (2004). The use of the stable free radical diphenylpicrylhydrazyl (DPPH) for estimating antioxidant activity. Songklanakarin J. sci. technol, 26(2), 211-219.
Salamah, N., & Widyasari, E. (2015). Aktivitas antioksidan ekstrak metanol daun kelengkeng (Euphoria longan (L) Steud.) dengan metode penangkapan radikal 2, 2’-difenil-1-pikrilhidrazil. Pharmaciana, 5(1), 25-34.
Seribu, D. K. (2006). Ansel, HC, 1989, Pengantar Bentuk Sediaan Farmasi, Edisi III, 602, 607-612, Departemen Kesehatan RI, Jakarta. Anonim, 1986, Sediaan Galenik, 5-17, Departemen Kesehatan RI, Jakarta. Anonim, 2002, Free Radical and Your Health (online). Food Chem, 83, 547-550.
Sihombing, C. N., Nasrul, W., & Taofik, R. (2010). Formulasi Gel Antioksidan Ekstrak Buah Buncis (Phaseolus vulgaris L.) dengan Menggunakan Basis Aqupec 505 HV. Jurnal ilmiah universitas padjadjaran.
Sriningsih. 2008. Analisa Senyawa Golongan Flavonoid dari Daun Dewan daru (Eugenia uniflora L.). Skripsi. Tersediadalam
van Steenis, C. G. G. J., Bloembergen, S., & Eyma, P. J. (2002). Flora, diterjemahkan oleh Surjowinoto. M., Hardjosuwarno, S., Adisewojo, SS, Wibisono, Partodidjojo, M., Wirjahardja, S., cetakan, 8, 378-382.
Wathoni N, Rusdiana T, Hutagaol RY. 2012. Formulasi Gel Antioksi dan Ekstrak Rimpang Lengkuas (Alpinia galanga L.Willd) dengan Menggunakan Basis Aqupec 505 HV.Jatinangor Fakultas Farmasi, Universitas Padjadjran
Winarsi, H. (2007). Antioksidan alami & radikal bebas.
Zhang, L. L., & Lin, Y. M. (2009). Antioxidant tannins from Syzygium cumini fruit. African Journal of Biotechnology, 8(10).