Is There Any Effect Of Addictions In Arsenic Induced Oral Carcinoma?

Effect of various addictions in arsenic related OSCC

  • Pritha Pal Mrs. Pritha Pal, Senior Research Fellow, Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission SevaPratishthan, 99 Sarat Bose Road, Kolkata- 700026, West Bengal, India
  • Ranjan Raychowdhury Professor, Department of ENT-Head & Neck Surgery, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, 99 Sarat Bose Road, Kolkata- 700026, West Bengal, India.
  • Sandeep Poddar Senior Research Director, Lincoln University College, 47301 Petaling Jaya, Selangor D. E., Malaysia
  • Ajanta Halder Associate Professor, Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, 99 Sarat Bose Road, Kolkata- 700026, West Bengal, India.


Background- The association of various addictions with oral squamous cell carcinoma (OSCC) has been well established. But it’s any possible link with metal toxicity has not been studied in the context of this carcinoma.

Aim- To correlate the variation in the effect of various addictions with arsenic toxicity in the development of OSCC in the study population.

Settings and design- It is a case-control study. Ethical clearance was obtained from the institutional committee. A total of 104 oral malignant, 103 premalignant and 200 age and sex matched healthy individuals were selected for the study. The history of addictions of case and controls was collected from questionnaire.

Methods and material- On proper consent of cases & controls, the hair samples were collected for arsenic estimation by flow injection hydride generation atomic absorption spectrometry and the peripheral venous blood samples were processed for human leukocyte culture followed by Giemsa staining for the detection of chromosomal abnormality.

Statistical analysis used- Student t test, logistic regression by R software and correlation analysis by Graph Pad software.

Results- Significant correlation was observed between arsenic toxicity & OSCC (p value = 2.18e-06 ***). Smoking tobacco (r value 0.5365) was more significant over chewing tobacco (r value 0.4804). 3% of malignant cases showed chromosomal break.

Conclusion- Statistically significant correlation among arsenic, addictions & OSCC in this study may indicate an associative role between the two factors. However, the study could not define any correlation with cytogenetic damage.

Keywords: oral carcinoma, arsenic toxicity, addictions, chromosomal abnormality


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Pal, P., Raychowdhury, R., Poddar, S., & Halder, A. (2019). Is There Any Effect Of Addictions In Arsenic Induced Oral Carcinoma?. International Journal of Advancement in Life Sciences Research, 2(2), 36-42. Retrieved from