Development and Statistical Optimization of Polyherbal Tablets Containing Indigenous Plant Extracts

Umesh Annappan; Kumudhavalli M V; Kumar Mohan

doi:10.31632/ijalsr.2024.v07i03.009

Umesh Annappan Department of Pharmacy, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation-Deemed to be University (VMRFDU), Sankari Main Road, Ariyanoor, Salem-636008, Tamil Nadu, India. & Department of Pharmacognosy, Grace College of Pharmacy, Palakkad-678004, Kerala, India. https://orcid.org/0009-0008-9504-7712
Kumudhavalli M V Department of Pharmacy, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation-Deemed to be University (VMRFDU), Sankari Main Road, Ariyanoor, Salem-636008, Tamil Nadu, India. https://orcid.org/0000-0001-6675-8883
Kumar Mohan Department of Pharmacy, Vinayaka Mission’s College of Pharmacy, Vinayaka Mission’s Research Foundation-Deemed to be University (VMRFDU), Sankari Main Road, Ariyanoor, Salem-636008, Tamil Nadu, India. https://orcid.org/0000-0002-3513-2383

DOI https://doi.org/10.31632/ijalsr.2024.v07i03.009

Abstract

Background: The study of herbal medicine has grown tremendously in the last few decades. Because of its natural origin and minimal adverse effects, it is becoming progressively more popular in countries that are developing as well as developed. The polyherbal tablet formulation includes significant phytoconstituents like glycosides, alkaloids, flavanoids, tannins, phenols, steroids, and terpenoids. These substances have a great chance of treating a wide range of diseases. Objectives: Development and Statistical Optimization of polyherbal tablet containing B. diffusa, E. prostrata, P. amarus, and S. nigrum hydroalcoholic entire plant extracts by applying 2² factorial design. Materials and methods: Selected entire plants were used for the preparation of hydroalcoholic extracts. The wet granulation techniques were used to prepare polyherbal tablets using HPMC, Starch, and Gelatin, as a polymer. The objective aimed to optimize the polyherbal formulation, in addition to the quality of the formulation was assessed by evaluating various types of pre- and post-compression properties. Results: Selected plant extracts were exposed to preliminary phytochemical investigation, which shown the presence of steroids, alkaloids, glycosides, tannins, phenols, flavanoids, and triterpenoids. The preformulation study's results on the granules' various parameters have been shown to be satisfactory. Polyherbal tablets consisting dried entire plant hydroalcoholic extracts of B. diffusa, E. prostrata, P. amarus, and S. nigrum were made utilizing wet granulation procedures. In order to optimize, 2² full factorial designs were used, with the amount of MCC (X2) and the amount of gelatin (X1) serving as the independent variables. The examination of hardness 6.125 kg/cm² and friability 0.250% revealed that the F2 formulation was the most effective one. Conclusion: With an increase in MCC and gelatin content, the tablets' hardness significantly increased. The friability parameters are highly influenced by an ideal concentration of gelatin. When developing herbal tablets, a mixture of gelatin and MCC is the ideal combination of excipients.

Keywords: Gelatin, Hydroalcoholic extract, MCC, Polyherbal Tablet, wet granulation

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References

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