Ethanol Extract Dry Syrup Granulation Formulation Dayak Onion Bulb (Eleutherine bulbosa (Mill.) Urb.)
Abstract
Background: Dayak onion (Eleutherine bulbosa (Mill.) Urb.) is one kind of medicinal plant native to East Kalimantan that has antioxidant activity. The dosage form that can be developed is dry syrup granules which become one of the most simple dosage forms in preparation, easy to use, storage-stable and can cover the bitter taste of the drug. The goal of this study was to find the best mix of Avicel PH 101 and Na CMC to make dry syrup granules that meet the requirements for physical properties. Methods: Research was carried out experimentally using three formulas with combinations of Avicel PH 101 and Na-CMC. The ratios of Avicel PH 101 and Na-CMC were (1:0); (0.5:0.5) and (0:1). The evaluation of dry syrup granules included organoleptic observations, a moisture content test, a flowability test, a reconstitution time test, pH test, viscosity test and a hygroscopic test. Result: dry syrup granules with variation 1:0 of Avicel PH 101 and Na-CMC have the best requirements for physical properties, i.e. moisture content of 2.47%, the flow time of 0.91 seconds, an angle of repose 25.19 ° and tap index of 10.67%. Conclusion: Dry syrup granules with a ratio of Avicel PH 101 and Na CMC (1:0) are preparations that best meet the physical properties requirements, namely moisture content of 2.47%, flow time of 0.91 seconds, angle of repose 25, 19° and a fixing index of 10.67%.
Keywords:
Dry syrup granules, dayak onion extract, Avicel PH 101, Na-CMC
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References
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Prayitno, M. and Mukti, BH. (2020). Optimasi Potensi Bawang Dayak (Eleutherine Sp.) Sebagai Bahan Obat Alternatif. Jurnal Pendidikan Hayati. 4(3): 149-158. https://jurnal.stkipbjm.ac.id/index.php/JPH/article/view/436/231.
Rahayu, S. and Anisah, N. (2021). Pengaruh Variasi Konsentrasi Amprotab Sebagai Desintegrant Terhadap Sifat Fisik Tablet Ekstrak Buah Pare (Momordica charantia L.). Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan. 6(1): 39–48. https://doi.org/10.36387/jiis.v6i1.572.
Sa'adah, H., Fudholi, A. (2011). Optimization of Theophylline Tablet Formula Using CoProcessed Excipients of Lactose and Avicel. Majalah Farmasi Indonesia. 22(4): 306-314. https://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/648.
Sharon.N, Anam.S, Yuliet. (2013). Formlasi Krim Anitioksidan Ekstrak Etanol Bawang Hutan (Eleutherine palmifolia L. Merr). Online Jurnal of Natural Science. 2(3) : 111-122. http://jurnal.untad.ac.id/jurnal/index.php/ejurnalfmipa/article/view/1872.
Supomo, S., Bella R.W, D., & Sa’adah, H. (2015). Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia mangostana. L) Menggunakan Aerosil dan Avicel PH 101. Journal of Tropical Pharmacy and Chemistry, 3(2), 131–137. https://doi.org/10.25026/jtpc.v3i2.99.
Syamsul, E., Supomo, S., Wijaya, H., & Nugroho, B. (2020). Ethanolic Extract Formulation Of Bawang Tiwai (Eleutherine americana) In Antiacne Cream. Majalah Obat Tradisional, 20(3), 149-157. http://dx.doi.org/10.22146/tradmedj.8860*/ doi:https://doi.org/10.22146/tradmedj.8860
Zakaria, N. H., Saad, N., Che Abdullah, C. A., & Mohd Esa, N. (2023). The Antiproliferative Effect of Chloroform Fraction of Eleutherine bulbosa (Mill.) Urb. on 2D- and 3D-Human Lung Cancer Cells (A549) Model. Pharmaceuticals (Basel, Switzerland), 16(7), 936. https://doi.org/10.3390/ph16070936
Anil, A., & Sudheer, P. (2018). Mucoadhesive Polimers: A. Review. Journal of Pharmaceutical Research, 17(1), 48-55. https://japsonline.com/admin/php/uploads/209_pdf.pdf.
da Silva, R. M. G., Alves, C. P., Barbosa, F. C., Santos, H. H., Adão, K. M., Granero, F. O., ... & Silva, L. P. (2024). Antioxidant, antitumoral, antimetastatic effect and inhibition of collagenase enzyme activity of Eleutherine bulbosa (Dayak onion) extract: In vitro, in vivo and in silico approaches. Journal of Ethnopharmacology, 318, 117005. https://doi.org/10.1016/j.jep.2023.117005
Elisabeth, V., YamLean, P. V. Y. and Supriati, H. S. (2018). Formulasi Sediaan Granul dengan Bahan Pengikat Pati Kulit Pisang Goroho (Musa acuminafe L.) dan Pengaruhnya pada Sifat Fisik Granul. Jurnal Ilmiah Farmasi, 7(4): 1–11. https://ejournal.unsrat.ac.id/v3/index.php/pharmacon/article/view/21416.
Hafizah, A., Wardana, D., & Pratiwi, A. (2017). Formulasi Sediaan Suspensi Menggunakan Suspending Agent Dari Biji Salak Pondoh (Sallaca Zallaca (Gaertn).Voss) Dan Biji Buah Salak Bali (Sallaca Zallaca Ertn) Var. Amboinensis (Becc) Mogea. Jurnal Ilmu Kesehatan Dan Farmasi, 5(2), 43-48. https://doi.org/10.51673/jikf.v5i2.551.
Habibah, N. A., Lutfiah, A., Liana, A., Tunjung, W. A. S., Indrowati, M., & Pa’ee, F. (2023). Callogenesis of Dayak Onion (Eleutherine palmifolia) Bulb in response of Picloram, 2, 4-D, and Kinetin. Biosaintifika: Journal of Biology & Biology Education, 15(2), 270-280. https://doi.org/10.15294/biosaintifika.v15i2.46501
Harahap, H. Y., Futri, C. L., Aminah, D., & Tri, W. (2023). Dayak Onion Tuber (Eleutherine Bulbosa (Mill)(Urb) Extract Ethanol Test on The Histopatological Description of Pancreas Wistar Rat Inducted Streptozotocin. KnE Social Sciences, 772-780. https://doi.org/10.18502/kss.v8i4.12972
Harlita, T. D., Oedjijono, & Asnani, A. (2018). The Antibacterial Activity of Dayak Onion (Eleutherine palmifolia (L.) Merr) towards Pathogenic Bacteria. Tropical Life Sciences Research, 29(2), 39–52. https://doi.org/10.21315/tlsr2018.29.2.4
Kamarudin, A. A., Sayuti, N. H., Saad, N., Razak, N. A. A., & Esa, N. M. (2022). Induction of apoptosis by Eleutherine bulbosa (Mill.) Urb. bulb extracted under optimised extraction condition on human retinoblastoma cancer cells (WERI-Rb-1). Journal of Ethnopharmacology, 284, 114770. https://doi.org/10.1016/j.jep.2021.114770
Kokafrinsia, Z. T. and Saryanti, D. (2021). Optimasi Campuran Avicel PH 101 dan Laktosa sebagai Bahan Pengisi pada Tablet Ekstrak Bunga Rosella (Hibiscus sabdariffa L.) Secara Granulasi Basah. Jurnal Riset Kefarmasian Indonesia, 3(2):102–116. https://doi.org/10.33759/jrki.v3i2.124.
Kusumaningrum, ID.,Wardani, CC. (2020). Pengaruh konsentrasi Natrii Carboxymethylcellulosum (CMC Na) sebagai suspending agent terhadap stabilitas fisik pada sediaan suspensi kloramfenikoL. Pharmaceutical and Traditional Medicine, 1(2), 84-89. http://www.lppm.poltekmfh.ac.id/index.php/ptm/article/view/77.
Luh, Ni Indrawati dan Razimin. (2013). Bawang Dayak Si Umbi Ajaib Penakluk Aneka Penyakit. Agromedia Pustaka: Jakarta.
Munaeni, W., Yuhana, M., Setiawati, M., & Wahyudi, A. T. (2019). Phytochemical analysis and antibacterial activities of Eleutherine bulbosa (Mill.) Urb. extract against Vibrio parahaemolyticus. Asian Pacific Journal of Tropical Biomedicine, 9(9), 397-404. https://doi.org/10.4103/2221-1691.267669
Ofner III, C. M., Schnaare, R. L., dan Schwartz, J.B. (1989). Pharmaceutical Suspensions. Di dalam: Lieberman H.A., Rieger,M. M., dan Banker, G. S. (eds.) Pharmaceutical Dosage Forms: Disperse Systems. Vol 2. Marcel Dekker, Inc: New York. page: 243-258.
Prayitno, M. and Mukti, BH. (2020). Optimasi Potensi Bawang Dayak (Eleutherine Sp.) Sebagai Bahan Obat Alternatif. Jurnal Pendidikan Hayati. 4(3): 149-158. https://jurnal.stkipbjm.ac.id/index.php/JPH/article/view/436/231.
Rahayu, S. and Anisah, N. (2021). Pengaruh Variasi Konsentrasi Amprotab Sebagai Desintegrant Terhadap Sifat Fisik Tablet Ekstrak Buah Pare (Momordica charantia L.). Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan. 6(1): 39–48. https://doi.org/10.36387/jiis.v6i1.572.
Sa'adah, H., Fudholi, A. (2011). Optimization of Theophylline Tablet Formula Using CoProcessed Excipients of Lactose and Avicel. Majalah Farmasi Indonesia. 22(4): 306-314. https://indonesianjpharm.farmasi.ugm.ac.id/index.php/3/article/view/648.
Sharon.N, Anam.S, Yuliet. (2013). Formlasi Krim Anitioksidan Ekstrak Etanol Bawang Hutan (Eleutherine palmifolia L. Merr). Online Jurnal of Natural Science. 2(3) : 111-122. http://jurnal.untad.ac.id/jurnal/index.php/ejurnalfmipa/article/view/1872.
Supomo, S., Bella R.W, D., & Sa’adah, H. (2015). Formulasi Granul Ekstrak Kulit Buah Manggis (Garcinia mangostana. L) Menggunakan Aerosil dan Avicel PH 101. Journal of Tropical Pharmacy and Chemistry, 3(2), 131–137. https://doi.org/10.25026/jtpc.v3i2.99.
Syamsul, E., Supomo, S., Wijaya, H., & Nugroho, B. (2020). Ethanolic Extract Formulation Of Bawang Tiwai (Eleutherine americana) In Antiacne Cream. Majalah Obat Tradisional, 20(3), 149-157. http://dx.doi.org/10.22146/tradmedj.8860*/ doi:https://doi.org/10.22146/tradmedj.8860
Zakaria, N. H., Saad, N., Che Abdullah, C. A., & Mohd Esa, N. (2023). The Antiproliferative Effect of Chloroform Fraction of Eleutherine bulbosa (Mill.) Urb. on 2D- and 3D-Human Lung Cancer Cells (A549) Model. Pharmaceuticals (Basel, Switzerland), 16(7), 936. https://doi.org/10.3390/ph16070936
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How to Cite
Sukawaty, Y., Sa`adahH., Wijaya, H., & Austin, G. (2024). Ethanol Extract Dry Syrup Granulation Formulation Dayak Onion Bulb (Eleutherine bulbosa (Mill.) Urb.). International Journal of Advancement in Life Sciences Research, 7(1), 103-109. https://doi.org/https://doi.org/10.31632/ijalsr.2024.v07i01.011
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