Periscopic View on COVID 19 Infection: A Review

Periscopic View on COVID 19 Infection


Recently, the world has experienced an unprecedented health risk. The unknown coronavirus (SARS-CoV-2 causing COVID-19) is causing a pandemic infection as announced by World Health Organization. It emerged from Wuhan, China in December 2019 and spread worldwide. The SARS-CoV-2 originated in bats and through yet unknown intermediary animals was transmitted to humans in Wuhan. There have been around 3,935,559 reported cases of coronavirus disease 2019 (COVID-2019) and 271,170 reported deaths to date (08/05/2020). It spreads mainly through the droplet route by inhalation or contact. Incubation period 1-14 d. Asymptomatic or patients with mild symptoms is most common of the cases; case fatality nearly 2-3%). The major symptoms are fever, dry cough, fatigue and muscle pain; less common symptoms reported are runny nose, sore throat, diarrhea, chills and hemoptysis. The SARS-CoV-2 infection is a life-threatening complication of acute respiratory distress syndrome (ARDS); in severe cases with other co-morbidities, which most commonly occurs more often in elderly or immunocompromised individuals with underlying diseases. Severe expression of the infection needs treatment in the intensive care unit with indications of acute lung inflammation, ARDS, sepsis and septic shock. Diagnosis of virus in respiratory secretions is done by special molecular tests. This review presents information about history, etiology, pathogenesis, clinical diagnostics, treatment and prevention of the infection. At present, the effective antiviral drug or vaccine is not yet available and the number of infections/death tolls surging day by day, so updated knowledge of this infection is always needed prevention for fighting the virus.

Keywords: Coronaviruses, COVID-19, SARS-CoV-2, acute respiratory distress syndrome (ARDS), SIRS.


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Aiping, W., Yousong, P., Baoying, H., Xiao, D., Xianyue, W., Peihua, N., Jing, M., Zhaozhong, Z., Zheng, Z., Jiangyuan, W., Jie, S., Lijun, Q., Zanxian, X., Wenjie,., Genhong, C., Taijiao,. J. (2020). Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China. Cell Host & Microbe, 27(3),325–328. doi: 10.1016/j.chom.2020.02.001.
Angeletti, S., Benvenuto, D., Bianchi, M., Giovanetti, M., Pascarella, S., Ciccozzi M. ( 2020). COVID-2019: the role of the nsp2 and nsp3 in its pathogenesis. J Med Virol , 92(6),584-588. doi: 10.1002/jmv.25719. Epub 2020 Feb 28.
Assiri, A., Al-Tawfiq, JA., Al-Rabeeah, AA., Al-Rabiah, FA., Al-Hajjar, S., Al-Barrak, A., Flemban, H., Al-Nassir, WN., Balkhy, HH., Al-Hakeem, RF., Makhdoom, HQ., Zumla, AI., Memish, ZA. (2013). Epidemiological, demographic, and clinical characteristics of 47 cases of Middle East respiratory syndrome coronavirus disease from Saudi Arabia: a descriptive study. Lancet Infect Dis , 13(9),752-61. doi: 10.1016/S1473-3099(13)70204-4. Epub 2013 Jul 26.
Banerjee, A., Kulcsar, K., Misra, V., Frieman, M., Mossman, K. (2019). Bats and Coronaviruses. Viruses, 9;11(1), pii: E41. doi: 10.3390/v11010041.
Banerjee, S., Dhar, S., Bhattacharjee, S., Bhattacharjee, P . (2020). Decoding the lethal effect of SARS-CoV-2 (novel coronavirus) strains from global perspective: molecular pathogenesis and evolutionary divergence. bioRxiv, preprint doi:
Chan, JF., Yuan, S., Kok, KH., To, KK., Chu, H., Yang, J., Xing, F., Liu, J., Yip, CC., Poon, RW., Tsoi , HW., Lo, SK., Chan, KH., Poon, VK., Chan, WM., Ip, JD., Cai, JP., Cheng, VC., Chen, H., Hui, CK., Yuen, KY. (2020). A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet, 15;395(10223),514-523. doi: 10.1016/S0140-6736(20)30154-9. Epub 2020 Jan 24.
Chan-Yeung, M., Xu, RH. (2003). SARS: epidemiology. Respirology, 8,S9–14. doi: 10.1046/j.1440-1843.2003.00518.x.
Chen, L. , Xiong, J., Bao, L., Shi, Y. (2020). Convalescent plasma as a potential therapy for COVID-19. Lancet Infect Dis ,20(4),398-400. doi:10.1016/S1473-3099(20)30141-9
Chen, L., Liu, W., Zhang, Q., Xu, K., Ye, G., Wu, W., Sun, Z., Liu, F., Wu, K., Zhong, B., Mei, Y., Zhang, W., Chen, Y., Li, Y., Shi, M., Lan, K., Liu, Y. (2020). RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak. Emerg Microbes Infect, 5;9(1),313-319. doi: 10.1080/22221751.2020.1725399. eCollection 2020.
Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., Xia, J., Yu, T., Zhang, X., Zhang, L. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet, 15;395(10223),507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30.
Chen, Y., Peng, H., Wang, L., Zhao, Y., Zeng, L., Gao, H., Liu, Y. (2020). Infants Born to Mothers With a New Coronavirus (COVID-19). Front Pediatr, 16;8,104. doi: 10.3389/fped.2020.00104. eCollection 2020.
Chung, M., Bernheim, A., Mei, X., Zhang, N., Huang, M., Zeng, X., Cui, J., Xu, W., Yang, Y., Fayad, Z.A., Jacobi, A., Li, K., Li, S., Shan, H. (2020).CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV). Radiology, 295(1),202-207. doi: 10.1148/radiol.2020200230. Epub 2020 Feb 4.
COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU)". ArcGIS. Johns Hopkins University. Retrieved 8 May 2020.
Cui, J., Li, F., Shi, Z.L. (2019). Origin and evolution of pathogenic coronaviruses. Nat Rev Microbiol, 17(3),181–192. doi: 10.1038/s41579-018-0118-9.
Cui, J., Han, N., Streicker, D., Li, G., Tang, X., Shi, Z., Hu, Z., Zhao, G., Fontanet, A., Guan, Y., Wang, L., Jones, G., Field, H.E., Daszak, P., Zhang, S. (2007). Evolutionary relationships between bat coronaviruses and their hosts. Emerg Infect Dis, 13(10),1526-32. doi: 10.3201/eid1310.070448.
de Groot, RJ., Baker, SC., Baric, RS., Brown, CS., Drosten, C., Enjuanes, L., Fouchier RA, Galiano, M., Gorbalenya, AE., Memish, ZA., Perlman, S., Poon, LL., Snijder, EJ, Stephens, GM., Woo, PC., Zaki, AM., Zambon, M., Ziebuhr, J. (2013).Middle East respiratory syndrome coronavirus (MERS-CoV): announcement of the Coronavirus Study Group. J Virol, 87(14),7790-2. doi: 10.1128/JVI.01244-13. Epub 2013 May 15.
de Wilde, AH., Snijder, EJ., Kikkert, M., van Hemert, MJ. (2018). Host Factors in Coronavirus Replication. Curr Top Microbiol Immunol, 419,1-42. doi: 10.1007/82_2017_25.
Drosten, C., Günther, S., Preiser, W., van der Werf, S., Brodt, H.R., Becker, S., Rabenau, H., Panning, M., Kolesnikova, L., Fouchier, R.A., Berger, A., Burguière, A.M., Cinatl, J., Eickmann, M., Escriou, N., Grywna, K., Kramme, S., Manuguerra, J.C., Müller, S., Rickerts, V., Stürmer, M., Vieth, S., Klenk, HD., Osterhaus, AD., Schmitz, H., Doerr, HW. (2003). Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med, 15;348(20),1967-76. Epub 2003 Apr 10.
Estola, T. (1970). Coronaviruses, a new group of animal RNA viruses. Avian Dis, 14(2),330-6.
Fung, SY., Yuen, KS., Ye, ZW., Chan, CP., Jin, DY. (2020). A tug-of-war between severe acute respiratory syndrome coronavirus 2 and host antiviral defence: lessons from other pathogenic viruses. Emerg Microbes Infect, 14;9(1),558-570. doi: 10.1080/22221751. 1736644. eCollection 2020.
Giovanetti, M., Benvenuto, D., Angeletti, S., Ciccozzi, M. (2020). The first two cases of 2019-nCoV in Italy: Where they come from? J Med Virol, 92(5),518-521. doi: 10.1002/jmv.25699. Epub 2020 Feb 12.
Gorbalenya, AE. , Baker, SC., Baric, RS., de Groot, RJ., Drosten, Christian., Gulyaeva, AA., Haagmans, BL., Lauber, Chris., Leontovich, A M., Neuman, BW., Penzar, Dmitry., Perlman, Stanley., Poon, LLM., Samborskiy, D., Sidorov, IA., Sola, I., Ziebuhr, J . ( 2020). Severe acute respiratory syndrome-related coronavirus: The species and its viruses – a statement of the Coronavirus Study Group. bioRxiv preprint first posted online February 11,. 2020:2020.2002.2007.937862. doi:10.1101/2020.02.07.937862.
Gouilh, MA., Puechmaille, SJ., Gonzalez, JP., Teeling, E., Kittayapong, P., Manuguerra, JC. (2011). SARS-Coronavirus ancestor’s foot-prints in South-East Asian bat colonies and the refuge theory. Infect Genet Evol, 11(7), 1690–1702. doi: 10.1016/j.meegid.2011.06.021. Epub 2011 Jul 8.
Guan, WJ., Ni, ZY., Hu, Y., Liang, WH., Ou, CQ., He, JX., Liu, L., Shan, H., Lei, CL., Hui, DSC., Du, B., Li, LJ., Zeng, G., Yuen, KY., Chen, RC., Tang, CL., Wang, T., Chen, PY., Xiang, J., Li, SY., Wang, JL., Liang, ZJ., Peng, YX., Wei, L., Liu, Y., Hu, YH., Peng, P., Wang, JM., Liu, JY., Chen, Z., Li, G., Zheng, Z.,J., Qiu, SQ., Luo, J., Ye, CJ., Zhu, S.Y., Zhong, NS., China Medical Treatment Expert Group for Covid-19. (2020).Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med, 382(18),1708-1720. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28.
Guo, YR., Cao, QD., Hong, ZS., Tan, YY., Chen, SD, Jin, HJ., Tan, KS, Wang, DY., Yan, Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res, 7(1),11. doi: 10.1186/s40779-020-00240-0.
Hamming, I., Timens, W., Bulthuis, ML., Lely, AT., Navis, G., van Goor, H. (2004). Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol, 203(2),631-7.
Hampton, T. (2005). Bats may be SARS reservoir. JAMA. 9;294(18),2291.
Holshue, ML., DeBolt, C., Lindquist, S., Lofy, KH., Wiesman, J., Bruce, H., Spitters, C., Ericson, K., Wilkerson, S., Tural, A., Diaz, G., Cohn, A., Fox, L., Patel, A., Gerber, SI., Kim, L., Tong. S., Lu, X., Lindstrom, S., Pallansch, MA., Weldon, WC., Biggs, HM., Uyeki, TM., Pillai, SK., Washington State 2019-nCoV Case Investigation Team. (2020). First Case of 2019 Novel Coronavirus in the United States. N Engl J Med, 5;382(10),929-936. doi: 10.1056/NEJMoa2001191. Epub 2020 Jan 31.
Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., Zhang, L., Fan, G., Xu, J., Gu, X., Cheng, Z., Yu, T., Xia, J., Wei, Y., Wu, W., Xie, X., Yin, W., Li, H., Liu, M., Xiao, Y., Gao, H., Guo, L., Xie, J., Wang, G., Jiang, R., Gao, Z., Jin, Q., Wang, J., Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 15;395(10223),497-506. doi: 10.1016/S0140-6736(20)30183-5. Epub 2020 Jan 24.
Hussain, S., Pan, J., Chen, Y., Yang, Y., Xu, J., Peng, Y., Wu, Y., Li, Z., Zhu, Y., Tien, P., Guo, D. (2005). Identification of novel subgenomic RNAs and noncanonical transcription initiation signals of severe acute respiratory syndrome coronavirus. J Virol, 2005 79(9),5288-95. Immunol. 2020.
Jia, HP., Lookm DC., Shi, L., Hickey, M., Pewe, L., Netland, J., Farzan, M., Wohlford-Lenane, C., Perlman, S., McCray, PB Jr. (2005). ACE2 receptor expression and severe acute respiratory syndrome coronavirus infection depend on differentiation of human airway epithelia. J Virol, 79(23),14614-21.
Jin, YH., Cai, L., Cheng, ZS., Cheng, H., Deng, T., Fan, YP., Fang, C., Huang, D., Huang, LQ., Huang, Q., Han, Y., Hu, B., Hu, F., Li, BH., Li, YR., Liang, K., Lin, LK., Luo, LS., Ma, J., Ma, LL., Peng, ZY., Pan, YB., Pan, ZY., Ren, XQ., Sun, HM., Wang, Y., Wang, YY., Weng, H., Wei, CJ., Wu, DF., Xia, J., Xiong, Y., Xu, HB., Yao, XM., Yuan, YF., Ye, TS., Zhang, XC., Zhang, YW., Zhang, YG., Zhang, HM., Zhao, Y., Zhao, MJ., Zi, H., Zeng, XT., Wang, YY., Wang, XH., for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM). (2020). A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version). Mil Med Res, 6;7(1),4. doi: 10.1186/s40779-020-0233-6.
Kendall, EJ., Bynoe, ML., Tyrrell, DA. (1962). Virus isolations from common colds occurring in a residential school. Br Med J, 14;2(5297),82-6.
Kirchdoerfer, RN., Cottrell, CA., Wang, N., Pallesen, J., Yassine, HM., Turner, HL., Corbett, KS., Graham, BS., McLellan, JS., Ward, AB. (2016). Pre-fusion structure of a human coronavirus spike protein. Nature, 3;531(7592),118-21. doi: 10.1038/nature17200.
Ksiazek, TG., Erdman, D., Goldsmith, CS., Zaki, SR., Peret, T., Emery, S., Tong, S., Urbani, C., Comer, JA., Lim, W., Rollin, PE., Dowell, SF., Ling, AE., Humphrey, CD., Shieh, WJ., Guarner, J., Paddock, CD., Rota, P., Fields, B., DeRisi, J., Yang, JY., Cox, N., Hughes, JM., LeDuc, JW., Bellini, WJ., Anderson, LJ., SARS Working Group. (2003). A novel coronavirus associated with severe acute respiratory syndrome. N Engl J Med, 15;348(20),1953-66. Epub 2003 Apr 10.
Lam, TT., Shum, MH., Zhu, HC., Tong, YG., Ni, XB., Liao, YS., Wei, W., Cheung, WY., Li, WJ., Li, LF., Leung, GM., Holmes, EC., Hu, YL., Guan, Y. (2020). Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins. Nature, 583(7815),282-285. doi: 10.1038/s41586-020-2169-0.
Lau, SK., Woo, PC., Yip, CC., Tse, H., Tsoi, HW., Cheng, VC., Lee, P., Tang, BS., Cheung, CH., Lee, RA., So, LY., Lau, YL., Chan, KH., Yuen, KY. (2006). Coronavirus HKU1 and other coronavirus infections in Hong Kong. J Clin Microbiol, 44(6),2063-71.
Lee, N., Hui, D., Wu, A., Chan, P., Cameron, P., Joynt, GM., Ahuja, A., Yung, MY., Leung, CB., To, KF., Lui, SF., Szeto, CC., Chung, S., Sung, JJ. (2003). A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med, 15;348(20),1986-94. Epub 2003 Apr 7.
Lee, PI., Hsueh, PR. (2020). Emerging threats from zoonotic coronaviruses-from SARS and MERS to 2019-nCoV. J Microbiol Immunol Infect, 4. pii: S1684-1182(20)30011-6. doi: 10.1016/j.jmii.2020.02.001.
Letko, M., Marzi, A., Munster, V. (2020). Functional assessment of cell entry and receptor usage for SARS-CoV-2 and other lineage B betacoronaviruses. Nat Microbiol, 5(4),562-569. doi: 10.1038/s41564-020-0688-y. Epub 2020 Feb 24.
Leung, WK., To, KF., Chan, PK., Chan, HL., Wu, AK., Lee, N,, Yuen, KY., Sung, JJ. (2003). Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology, 125(4),1011-7.
Li, H., Wang, YM., Xu, JY., Cao, B. (2020). Potential antiviral therapeutics for 2019 Novel Coronavirus. Zhonghua Jie He He Hu Xi Za Zhi, 12;43(3),170-172. doi: 10.3760/cma.j.issn.1001-0939.2020.03.004.
Li, Q. , Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, KSM., Lau, EHY., Wong, JY., Xing, X., Xiang, N., Wu, Y., Li, C., Chen, Q., Li, D., Liu, T., Zhao, J., Liu, M., Tu, W., Chen, C., Jin, L., Yang, R., Wang, Q., Zhou, S., Wang, R,, Liu, H., Luo, Y., Liu, Y,, Shao, G., Li, H., Tao, Z., Yang, Y., Deng, Z., Liu, B., Ma, Z., Zhang, Y., Shi, G., Lam, TTY., Wu, JT., Gao, GF., Cowling, BJ., Yang, B., Leung, GM., Feng, Z. (2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med, 26;382(13),1199-1207. doi: 10.1056/NEJMoa2001316. Epub 2020 Jan 29.
Li, Q., Guan, X., Wu, P., Wang, X., Zhou, L., Tong, Y., Ren, R., Leung, KSM., Lau, EHY., Wong, JY., Xing, X., Xiang, N., Wu, Y., Li, C., Chen, Q., Li, D., Liu, T., Zhao, J., Liu, M., Tu, W., Chen, C., Jin, L., Yang, R., Wang, Q., Zhou, S., Wang, R., Liu, H., Luo, Y., Liu, Y., Shao, G., Li, H., Tao, Z., Yang, Y., Deng, Z., Liu, B., Ma, Z., Zhang, Y., Shi, G,, Lam, TTY., Wu, JT., Gao, GF., Cowling, BJ., Yang, B., Leung, GM., Feng, Z. (2020). Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med, 26;382(13),1199-1207. doi: 10.1056/NEJMoa2001316. Epub 2020 Jan 29.
Li, W., Shi, Z., Yu, M., Ren, W., Smith, C,, Epstein, JH., Wang, H., Crameri, G., Hu, Z., Zhang, H., Zhang, J., McEachern, J., Field, H., Daszak, P., Eaton, BT., Zhang, S., Wang, LF. (2005). Bats are natural reservoirs of SARS-like coronaviruses. Science, 28;310(5748),676-9. Epub 2005 Sep 29.
Liu, Z., Xiao, X., Wei, X., Li, J., Yang, J., Tan, H., Zhu, J., Zhang, Q., Wu, J., Liu, L. (2020). Composition and divergence of coronavirus spike proteins and host ACE2 receptors predict potential intermediate hosts of SARS-CoV-2. J Med Virol, 92(6),595-601. doi: 10.1002/jmv.25726. Epub 2020 Mar 11.
Lu, H., Stratton, CW., Tang, YW. (2020). Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle. J Med Virol, 92(4),401-402. doi: 10.1002/jmv.25678. Epub 2020 Feb 12.
Lu, R., Zhao, X., Li, J., Niu, P., Yang, B., Wu, H., Wang, W., Song, H., Huang, B., Zhu, N., Bi, Y., Ma, X., Zhan, F., Wang, L., Hu, T., Zhou, H., Hu, Z., Zhou, W., Zhao, L., Chen, J., Meng, Y., Wang, J., Lin, Y., Yuan, J., Xie, Z., Ma, J., Liu, WJ., Wang, D., Xu, W., Holmes, EC., Gao, GF., Wu, G., Chen, W., Shi, W., Tan, W. (2020). Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet, 22;395(10224),565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30.
Mahase, E. (2020). Covid-19: Coronavirus was first described in The BMJ in 1965. BMJ, 16;369,m1547. doi: 10.1136/bmj.m1547.
McIntosh, K. (1974). Coronaviruses: a comparative review. Curr Top Microbiol Immunol, 63,85–129.
McIntosh, K., Dees, JH., Becker, WB., Kapikian, AZ., Chanock, RM. (1967). Recovery in tracheal organ cultures of novel viruses from patients with respiratory disease. Proc Natl Acad Sci USA, 1967;57,933–940.
Mehta, P., McAuleym DF., Brown, M., Sanchez, E., Tattersall, RS., Manson, JJ., HLH Across Speciality Collaboration, UK., (2020). COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet, 28;395(10229),1033-1034. doi: 10.1016/S0140-6736(20)30628-0. Epub 2020 Mar 16.
Middle East Respiratory Syndrome Coronavirus. Available at: Accessed 9 May 2020.
National Health Commission and State Administration of Traditional Chinese Medicine. Diagnosis and treatment protocol for novel coronavirus pneumonia. Accessed May 18, 2020.
National Health Commission of the People’s Republic of China. Diagnosis and Treatment of Pneumonia Caused by 2019-nCoV (version 6). 2020. Accessed 9 May 2020.
Paraskevis, D., Kostaki, EG., Magiorkinis, G., Panayiotakopoulos, G., Sourvinos, G., Tsiodras, S. (2020). Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event. Infect Genet Evol, ;79:104212. doi: 10.1016/j.meegid.2020.104212. Epub 2020 Jan 29.
Peiris, JS., Lai, ST., Poon, LL., Guan, Y., Yam, LY., Lim, W., Nicholls, J., Yee, WK., Yan, WW., Cheung, MT., Cheng, VC., Chan, KH., Tsang, DN., Yung, RW., Ng, TK., Yuen, KY., SARS study group. (2003). Coronavirus as a possible cause of severe acute respiratory syndrome. Lancet, 19;361(9366),1319-25.
Pene, F., Merlat, A., Vabret, A., Rozenberg, F., Buzyn, A., Dreyfus, F., Cariou, A., Freymuth, F., Lebon, P. (2003). Coronavirus 229E-related pneumonia in immunocompromised patients. Clin Infect Dis, 1;37(7),929-32. Epub 2003 Sep 8.
Perlman, S., Netland, J. (2009). Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol, 7(6),439-50. doi: 10.1038/nrmicro2147.
Perrier, A., Bonnin, A., Desmarets, L., Danneels, A., Goffard, A., Rouillé, Y., Dubuisson, J., Belouzard, S. (2019). The C-terminal domain of the MERS coronavirus M protein contains a trans-Golgi network localization signal. J Biol Chem, 27;294(39),14406-14421. doi: 10.1074/jbc.RA119.008964. Epub 2019 Aug 9.
Pfefferle, S., Oppong, S., Drexler, JF., Gloza-Rausch, F., Ipsen, A., Seebens, A., Müller, MA., Annan, A., Vallo, P., Adu-Sarkodie, Y., Kruppa, TF., Drosten, C. (2009). Distant relatives of severe acute respiratory syndrome coronavirus and close relatives of human coronavirus 229E in bats, Ghana. Emerg Infect Dis, 15(9),1377-84. doi: 10.3201/eid1509.090224.
Phan, LT., Nguyen, TV., Luong, QC., Nguyen, TV., Nguyen, HT., Le, HQ., Nguyen, TT., Cao, TM., Pham, QD. (2020). Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam. N Engl J Med, 27;382(9),872-874. doi: 10.1056/NEJMc2001272. Epub 2020 Jan 28.
Phan, T. (2020). Genetic diversity and evolution of SARS-CoV-2. Infect Genet Evol, 81,104260. doi: 10.1016/j.meegid.2020.104260. Epub 2020 Feb 21.
Richman, DD., Whitley, RJ, Hayden, FG. (2016). Clinical virology, 4th edn. ASM Press, Washington.
Sanders, JM., Monogue, ML., Jodlowski, TZ., Cutrell, JB. (2020). Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review. JAMA, 13. doi: 10.1001/jama.2020.6019.
Sanjuán, R., Domingo-Calap, P. (2016). Mechanisms of viral mutation. Cell Mol Life Sci; 73(23), 4433–4448.
Sawicki, SG., Sawicki, DL. (2005). Coronavirus transcription: a perspective. Curr Top Microbiol Immunol, 287,31-55.
Stein, RA. (2011). Super-spreaders in infectious diseases. Int J Infect Dis, 15(8),e510-3. doi: 10.1016/j.ijid.2010.06.020. Epub 2011 Jul 6.
Tang, X., Wu, C., Li, X., Song, Y., Yao, X., Wu, X., Duan, Y., Zhang, H., Wang , Y., Qian, Z., Cui, J., Lu, J. (2020). On the origin and continuing evolution of SARS-CoV-2. Natl Sci Rev, 10.1093/nsr/nwaa036.
Tortorici, MA., Veesler, D. (2019). Structural insights into coronavirus entry. Adv Virus Res, 105, 93-116. doi: 10.1016/bs.aivir.2019.08.002. Epub 2019 Aug 22.
van der Hoek, L., Pyrc, K., Jebbink, MF., Vermeulen-Oost, W., Berkhout, RJ., Wolthers, KC., Wertheim-van Dillen, PM., Kaandorp, J., Spaargaren, J., Berkhout, B. (2004).Identification of a new human coronavirus. Nat Med, 10(4),368-73. Epub 2004 Mar 21.
van der Hoek, L., Sure, K., Ihorst, G., Stang, A., Pyrc, K., Jebbink, MF., Petersen, G., Forster, J., Berkhout, B., Uberla, K. (2005). Croup is associated with the novel coronavirus NL63. PLoS Med, 2(8),e240. Epub 2005 Aug 23.
Velavan, TP., Meyer, CG. (2020). The COVID-19 epidemic. Trop Med Int Health, 25(3),278-280. doi: 10.1111/tmi.13383. Epub 2020 Feb 16.
Wan, Y., Shang, J., Graham, R., Baric, RS., Li, F. (2020). Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus. J Virol, 17;94(7),e00127-20. doi: 10.1128/JVI.00127-20. Print 2020 Mar 17.
Wang, D., Hu, B., Hu, C., Zhu, F., Liu, X., Zhang, J., Wang, B., Xiang, H., Cheng, Z., Xiong, Y., Zhao, Y., Li, Y., Wang, X., Peng, Z. (2020).Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA, 7;323(11),1061-1069. doi: 10.1001/jama.2020.1585.
Wang, H., Xiao, X., Lu, J., Chen, Z., Li, K., Liu, H., Luo, L., Wang, M., Yang, Z. (2016).Factors associated with clinical outcome in 25 patients with avian influenza A (H7N9) infection in Guangzhou, China. BMC Infect Dis, 3;16(1),534.
Wang, J., Qi, H., Bao, L., Li, F., Shi, Y., National Clinical Research Center for Child Health and Disorders and Pediatric Committee of Medical Association of Chinese People's Liberation Army. (2020). A contingency plan for the management of the 2019 novel coronavirus outbreak in neonatal intensive care units. Lancet Child Adolesc Health, 4(4),258-259. doi: 10.1016/S2352-4642(20)30040-7. Epub 2020 Feb 7.
Wang, Y., Li, X., Liu, W., Gan, M., Zhang, L., Wang, J., Zhang, Z., Zhu, A., Li, F., Sun, J., Zhang, G., Zhuang, Z., Luo, J., Chen, D., Qiu, S., Zhang, L., Xu, D., Mok, CKP., Zhang, F., Zhao, J., Zhou, R., Zhao, J. (2020). Discovery of a subgenotype of human coronavirus NL63 associated with severe lower respiratory tract infection in China, 2018. Emerg Microbes Infect, 29;9(1),246-255. doi: 10.1080/22221751.2020.1717999. eCollection 2020.
Wei, Q., Wang, Y.,Ma, J., Han, J., Jiang, M., Zhao, Li.,Ye, Fei., Song, J., Liu, B., Wu, L., Tan,W., Wu, G., Gao, GF., Lio, J., (2020). Description of the first strain of 2019-nCoV, C-Tan-nCoV Wuhan Strain — National Pathogen Resource Center, China, 2020. China CDC Weekly , 2(6),
WHO. Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected. clinical-management-of-severe-acute-respiratory-infection-when-novelcoronavirus-( ncov)-infection-is-suspected. Accessed 9 May 2020.
Woo, PC., Lau, SK., Lam, CS., Lau, CC., Tsang, AK., Lau, JH., Bai, R., Teng, JL,, Tsang, CC., Wang, M., Zheng, BJ., Chan, KH., Yuen, KY. (2012). Discovery of seven novel Mammalian and avian coronaviruses in the genus delta coronavirus supports bat coronaviruses as the gene source of alphacoronavirus and betacoronavirus and avian coronaviruses as the gene source of gammacoronavirus and deltacoronavirus. J Virol, 86(7),3995-4008. doi: 10.1128/JVI.06540-11. Epub 2012 Jan 25.
World Health Organization. Clinical management of severe acute respiratory infection when COVID-19 is suspected. Updated March 13, 2020. Accessed May 09, 2020.
World Health Organization. (2005). Statement on the second meeting of the International Health Regulations Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV). 2020. at Published January 31, 2020.
World Health Organization. (2020). WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. 2020. at Published February 11, 2020.
Wu, D., Zou, S., Bai, T., Li, J., Zhao, X., Yang, L., Liu, H., Li, X., Yang, X., Xin, L., Xu, S., Zou, X., Li, X., Wang, A., Guo, J., Sun, B., Huang, W., Zhang, Y., Li, X., Gao, R., Shen, B., Chen, T., Dong, J., Wei ,H., Wang, S., Li, Q., Li, D., Wu, G., Feng, Z., Gao, GF., Wang, Y., Wang, D., Fan, M., Shu, Y. (2015). Poultry farms as a source of avian influenza A (H7N9) virus reassortment and human infection. Sci Rep, 15(5),7630. doi: 10.1038/srep07630.
Wu, F., Zhao, S., Yu, B., Chen, YM., Wang, W., Song, ZG., Hu, Y., Tao, ZW., Tian, JH., Pei, YY., Yuan, ML., Zhang, YL., Dai, FH., Liu, Y., Wang, QM., Zheng, JJ., Xu, L., Holmes, EC., Zhang, YZ. (2020). A new coronavirus associated with human respiratory disease in China. Nature, 579(7798),265-269. doi: 10.1038/s41586-020-2008-3. Epub 2020 Feb 3.
Xia, S., Zhu, Y., Liu, M., Lan, Q., Xu, W., Wu, Y., Ying, T., Liu, S., Shi, Z., Jiang, S., Lu, L. (2020). Fusion mechanism of 2019-nCoV and fusion inhibitors targeting HR1 domain in spike protein. Cell Mol Immunol, 17(7),765-767. doi: 10.1038/s41423-020-0374-2. Epub 2020 Feb 11.
Xu, J., Zhong, S., Liu, J., Li, L., Li, Y., Wu, X., Li, Z., Deng, P., Zhang, J., Zhong, N., Ding, Y., Jiang, Y. (2005).Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis. Clin Infect Dis, 15;41(8),1089-96. Epub 2005 Sep 12.
Xu, X., Chen, P., Wang, J., Feng, J., Zhou, H., Li, X., Zhong, W., Hao, P. (2020). Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission. Sci China Life Sci, 63(3),457-460. doi: 10.1007/s11427-020-1637-5.
Yao, X., Ye, F., Zhang, M., Cui, C., Huang, B., Niu, P., Liu, X., Zhao, L., Dong, E., Song, C., Zhan, S., Lu, R., Li, H., Tan, W., Liu, D. (2020). In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Clin Infect Dis, 28;71(15),732-739. doi: 10.1093/cid/ciaa237.
Yeung, ML., Yao, Y., Jia, L., Chan, JF., Chan, KH., Cheung, KF., Chen, H., Poon, VK., Tsang, AK., To, KK., Yiu, MK., Teng, JL., Chu, H., Zhou, J., Zhang, Q., Deng, W., Lau, SK., Lau, JY., Woo, PC., Chan, TM., Yung, S., Zheng, BJ,, Jin, DY., Mathieson, PW., Qin, C., Yuen, KY. (2016). MERS coronavirus induces apoptosis in kidney and lung by upregulating Smad7 and FGF2. Nat Microbiol, 22;1:16004. doi: 10.1038/nmicrobiol.2016.4.
Yu, F., Du, L., Ojcius, DM., Pan, C., Jiang, S. (2020). Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes Infect, 22(2),74-79. doi: 10.1016/j.micinf.2020.01.003.
Zaki, AM., van Boheemen, S., Bestebroer, TM., Osterhaus, AD., Fouchier, RA.(2012). Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med, 367,1814-20.
Zhang, L., Shen, FM., Chen, F., Lin, Z. (2020).Origin and evolution of the 2019 novel coronavirus. Clin Infect Dis, 28;71(15),882-883. doi: 10.1093/cid/ciaa112.
Zhang, N., Jiang, S., Du, L. (2014). Current advancements and potential strategies in the development of MERS-CoV vaccines. Expert Rev Vaccines, 13(6),761–74.
Zhang, W., Du, RH., Li, B., Zheng, XS., Yang, XL., Hu, B., Wang, YY., Xiao, GF., Yan, B., Shi, ZL., Zhou, P. (2020). Molecular and serological investigation of 2019- nCoV infected patients: implication of multiple shedding routes. Emerg Microbes Infect, 17;9(1),386-389. doi: 10.1080/22221751.2020.1729071.
Zhong, NS., Zheng, BJ., Li, YM., Poon, Xie ZH,, Chan, KH., Li, PH., Tan, SY., Chang, Q., Xie, JP., Liu, XQ., Xu, J., Li, DX., Yuen, KY., Peiris, Guan Y. (2003). Epidemiology and cause of severe acute respiratory syndrome (SARS) in Guangdong, People's Republic of China, in February, 2003. Lancet, 25;362(9393),1353-8.
Zhou, J., Li, C., Zhao, G., Chu, H., Wang, D., Yan, HH., Poon, VK., Wen, L., Wong, BH., Zhao, X., Chiu, MC., Yang, D., Wang, Y., Au-Yeung, RKH., Chan, IH., Sun, S., Chan, JF., To, KK., Memish, ZA., Corman, VM., Drosten, C., Hung, IF., Zhou, Y., Leung, SY., Yuen, KY. (2017). Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus. Sci Adv, 15;3(11),eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov.
Zhou, P., Yang, XL., Wang, XG., Hu, B., Zhang, L., Zhang, W., Si, HR., Zhu, Y., Li, B., Huang, CL., Chen, HD., Chen, J., Luo, Y., Guo, H., Jiang, RD., Liu, MQ., Chen, Y., Shen, XR., Wang, X., Zheng, XS., Zhao, K., Chen, QJ., Deng, F., Liu, LL., Yan, B., Zhan, FX., Wang, YY., Xiao, GF., Shi, ZL. (2020). A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature, 579(7798),270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3.
Zhu, N., Zhang, D., Wang, W., Li, X., Yang, B., Song, J., Zhao, X., Huang, B., Shi, W., Lu, R., Niu, P., Zhan, F., Ma, X., Wang, D., Xu, W., Wu, G., Gao, GF., Tan, W. (2020). China Novel Coronavirus Investigating and Research Team. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N Engl J Med, 20;382(8),727-733. doi: 10.1056/NEJMoa2001017.
Zumla, A., Hui, DS., Perlman, S. (2015). Middle East respiratory syndrome. Lancet,386,995–1007.
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Ansar, W. (2020). Periscopic View on COVID 19 Infection: A Review. International Journal of Advancement in Life Sciences Research, 3(3), 1-15. Retrieved from
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